EFFECT OF ORAL TRIPEPTIDE-COLLAGEN ON MICROCIRCULATION (NAIL FOLDS) AND SKIN WRINKLES

Authors

  • Diana Krisanti Jasaputra Department of Pharmacology, Faculty of Medicine, Christian Maranatha University, Bandung, Indonesia
  • Hani Surjati Master of Skin Ageing and Aesthetic Medicine, Faculty of Medicine, Christian Maranatha University, Bandung, Indonesia
  • Fen Tih Department of Biochemistry, Faculty of Medicine, Christian Maranatha University, Bandung, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v9i2.927

Keywords:

Collagen , Microcirculation, Nasolabial Fold , Reactive Oxygen Species

Abstract

Background: Accelerated aging is associated with increased exposure to reactive oxygen species (ROS), leading to lower collagen and elastin levels in the body. This reduction reduces microvascular activity, causing microcirculatory disorders and skin wrinkles. Administering collagen tripeptides can help improve the microcirculation system. Objective: This study aims to investigate the effects of collagen tripeptide on improving microcirculation, reducing skin wrinkles, and lowering excessive ROS toxicity. Method: The research method used is experimental with a pre-post study approach without using a control group and descriptive quantitative data analysis. We measured microcirculation using a microscope, quantified ROS levels with the QYM-DI microscope, and assessed nasolabial fold depth with an acupuncture needle. Results: The study results indicate that collagen tripeptide significantly improves microcirculation, reduces skin wrinkles, and decreases excessive ROS toxicity. The non-parametric Wilcoxon test results are as follows: (1) there is a significant difference before and after collagen tripeptide consumption in terms of microcirculation improvement (p = 0.000), reduction of skin wrinkles on the nasolabial folds (p = 0.008), and reduction of ROS (p = 0.000). This improves microcirculation, which in turn reduces skin wrinkles on the nasolabial folds. Conclusion: Consuming collagen tripeptide for three months can improve microcirculation, reduce skin wrinkles on the nasolabial folds, and reduces ROS.

Author Biography

Diana Krisanti Jasaputra, Department of Pharmacology, Faculty of Medicine, Christian Maranatha University, Bandung

Departement of Pharmacology

References

Khalil A, Humeau-Heurtier A, Gascoin L, Abraham P, Mahé G. Aging effect on microcirculation: A multiscale entropy approach on laser speckle contrast images. Med Phys. 2016;43(7):4008–16.

Wlaschek M, Maity P, Makrantonaki E, Scharffetter-Kochanek K. Connective tissue and fibroblast senescence in Skin Aging. J Invest Dermatol. 2021;141(4):985–92.

Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, et al. The Human Microcirculation: Regulation of Flow and beyond. Circ Res. 2016;118(1):157–72.

Gu Y, Han J, Jiang C, Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020;59:101036.

Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev. 2015;21:16–29.

de la Torre BG, Albericio F. Peptide therapeutics 2.0. Molecules. 2020;25(10):2019–21.

Ichihara Y, Kaneko M, Yamahara K, Koulouroudias M, Sato N, Uppal R, et al. Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure. Biomaterials. 2018;154:12–23.

Bojarska J. Amino acids and short peptides as anti-Aging “superfood.” Int J Nutr Sci. 2021;5(1):1039.

Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients. 2018;10(7):826.

Bertolazzi C, Cutolo M, Smith V, Gutierrez M. State of the art on nailfold capillaroscopy in dermatomyositis and polymyositis. Semin Arthritis Rheum. 2017;47(3):432–44.

Pathak Y. The Skin Aging Process and Anti-Aging Strategies. Biomed J Sci Tech Res. 2022;42(2).

El-Mesidy MS, Alaklouk WT, Azzam OA. Nasolabial fold correction through cheek volume loss restoration versus thread lifting: a comparative study. Arch Dermatol Res. 2020;312(7):473–80.

Zhang Y, Dai M, Yuan Z. Methods for the detection of reactive oxygen species. Anal Methods. 2018;10(38):4625–38.

Arciero JC, Causin P, Malgaroli F, 1 Department of Mathematical Sciences, IUPUI, 402 N. Blackford, LD 270, Indianapolis IN 46202, USA, 2 Department of Mathematics, University of Milan, via Saldini 50, 20133 Milano, Italy. Mathematical methods for modeling the microcirculation. AIMS Biophys. 2017;4(3):362–99.

Chen XL, Peng M, Li J, Tang BL, Shao X, Zhao F, et al. Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913. Sci Rep. 2017;(15716):1–13.

Sibilla S, Godfrey M, Brewer S, Budh-Raja A, Genovese L. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: Scientific background and clinical studies. Open Nutraceuticals J. 2015;8(1):29–42.

Lu S, Zhang S, Wang Y, Ni J, Zhao T, Xiao G. Anti-Skin Aging Effects and Bioavailability of Collagen Tripeptide and Elastin Peptide Formulations in Young and Middle-Aged Women. J Dermatol Sci Cosmet Technol. 2024;1(2):100019.

Maeda K. Skin-Moisturizing Effect of Collagen Peptides Taking Orally. J Nutr Food Sci. 2018;08(02):1–8.

Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M. Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. Int J Mol Sci. 2016;17(6):868.

Zhu N, Xu MH, Li Y. Bioactive Oligopeptides from Ginseng (Panax ginseng Meyer) Suppress Oxidative Stress-Induced Senescence in Fibroblasts via NAD+/SIRT1/PGC-1? Signaling Pathway. Nutrients. 2022;14(24):1–14.

Chen T, Hou H, Fan Y, Wang S, Chen Q, Si L, et al. Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway. J Photochem Photobiol B. 2016;165:34–41.

Laing S, Bielfeldt S, Ehrenberg C, Wilhelm KP. A Dermonutrient Containing Special Collagen Peptides Improves Skin Structure and Function: A Randomized, Placebo-Controlled, Triple-Blind Trial Using Confocal Laser Scanning Microscopy on the Cosmetic Effects and Tolerance of a Drinkable Collagen Suppleme. J Med Food. 2020;23(2):147–52.

Downloads

Published

2024-12-30

Issue

Vol. 9 No. 2 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA

Section

Research

Citation Check

License

Copyright (c) 2024 Diana Krisanti Jasaputra, Hani Surjati, Fen Tih

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish in Berkala Ilmiah Kedokteran Duta Wacana agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

This work is licensed under CC BY-SA 4.0